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Covalent binding of catechols to src family SH2 domains

✍ Scribed by Christopher T. Jagoe; Scott E. Kreifels; Jongming Li

Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
192 KB
Volume
7
Category
Article
ISSN
0960-894X

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✦ Synopsis

Src family SH2 domains contain an uncoupled cysteine residue, that, when arylated with air oxidized catechols, inhibits the protein from binding to otherwise high affinity peptide ligands. No inhibition is observed for Crk, Abl, or Grb2 SH2 domains.

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