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Alternating non-cross-resistant chemotherapy for non-Hodgkin's lymphoma of intermediate-grade and high-grade malignancy. A pilot study

✍ Scribed by Masatni Hirano; Masataka Okamoto; Fumio Maruyama; Kohji Ezaki; Kazuyuki Shimizu; Teruo Ino; Toshikazu Matsui; Ryo Sobue; Kouichi Shinkai; Hitoshi Miyazaki; Toshiyuki Nomura; Machiko Wakita


Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
557 KB
Volume
69
Category
Article
ISSN
0008-543X

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An alternating chemotherapy combination
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48 patients with intermediate or high-grade non-Hodgkin's lymphomas (NHL) received a CHOP based combination with the addition of etoposide on days 1 and 2, bleomycin days 1 and 10 and methotrexate 1.5 g/m2 on day 10 (MACOBLE). Their median age was 59 years, 20 (42 per cent) had an ECOG performance s

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In a multicentre phase 111 trial 146 previously untreated patients with high grade non-Hodgkin's lymphomas stage I1 IV were randomized to receive either four cycles of CHOEP (cyclophosphamide 750 mg/m2 iv d 1, doxorubicin 50 mg/m2 iv d 1, vincristine 2 mg iv d 1, etoposide 100 mg/m2 iv d 3-5, predni

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An intensive third generation regimen (P-VABEC) including adriamycin, etoposide, cyclophosphamide. vincristine, bleomycin and prednisolone was administered to 43 unselected elderly patients with intermediate or high-grade non-Hodgkin's lymphomas (NHL). The median age was 67, 40 per cent were Ann Arb

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Intermediate grade non-Hodgkin's lymphoma (IGNHL) is generally considered a radiosensitive tumor that can be controlled with moderate radiation doses. Cell-survival curves of cell lines derived from IGNHL have been typically described to exhibit small or no shoulder, implying inability to accumulate

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This is an analysis of the long-term follow-up data of 99 patients receiving HOAP-Bleo, IMVP-16 and PAC as salvage chemotherapy for refractory or relapsed intermediate or high grade non-Hodgkin's lymphomas. Most of the patients received HOAP-Bleo or PAC following failure of initial chemotherapy and