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Altered β-adrenergic response in mice lacking myotonic dystrophy protein kinase

✍ Scribed by Esther Llagostera; María Jesús Álvarez López; Cecilia Scimia; Daniele Catalucci; Marcelina Párrizas; Pilar Ruiz-Lozano; Perla Kaliman

Publisher: John Wiley and Sons
Year: 2011
Tongue: English
Weight: 226 KB
Volume: 45
Category: Article
ISSN: 0148-639X
DOI: 10.1002/mus.22256

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## Abstract Myotonic muscular dystrophy (DM) is characterized by abnormal skeletal muscle Na channel gating and reduced levels of myotonic dystrophy protein kinase (DMPK). Electrophysiological measurements show that mice deficient in __Dmpk__ have reduced Na currents in muscle. We now find that the