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Skeletal myopathy in mice over-expressing the human myotonic dystrophy protein kinase (DMPK) gene

✍ Scribed by Monica A. Narang; James D. Waring; Luc A. Sabourin; Evica Rajcan-Separovic; David Parry; Frank Jirik; Robert G. Korneluk

Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
383 KB
Volume
1
Category
Article
ISSN
1438-7506

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## Abstract Myotonic muscular dystrophy (DM) is characterized by abnormal skeletal muscle Na channel gating and reduced levels of myotonic dystrophy protein kinase (DMPK). Electrophysiological measurements show that mice deficient in __Dmpk__ have reduced Na currents in muscle. We now find that the