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Altered substrate specificity of herpes simplex virus thymidine kinase confers acyclovir-resistance

✍ Scribed by Darby, G.; Field, H. J.; Salisbury, S. A.

Book ID
109721648
Publisher
Nature Publishing Group
Year
1981
Tongue
English
Weight
317 KB
Volume
289
Category
Article
ISSN
0028-0836

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## Abstract We previously isolated an acyclovir (ACV)‐resistant herpes simplex virus type 1 (HSV‐1), strain TAR, from a child with Wiskott‐Aldrich syndrome. An acyclovir‐sensitive HSV‐1, strain TAS, had been isolated from the same patient before the isolation of HSV‐1 TAR. The TK protein of ACV‐sen