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Altered Regulation of Fibronectin Gene Expression in Werner Syndrome Fibroblasts

✍ Scribed by P. Rasoamanantena; R. Thweatt; J. Labat-Robert; S. Goldstein

Book ID
115601773
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
755 KB
Volume
213
Category
Article
ISSN
0014-4827

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The Werner syndrome (WS) is a segmental progeroid syndrome caused by a recessive mutation (WRN) mapped to 8p12. The replicative life spans of somatic cells cultured from WS patients are substantially reduced compared to agematched controls. Certain molecular concomitants of the replicative decline o