Altered rate of DNA replication in ageing human fibroblast cultures
β Scribed by PETES, T. D.; FARBER, R. A.; TARRANT, G. M.; HOLLIDAY, R.
- Book ID
- 109692962
- Publisher
- Nature Publishing Group
- Year
- 1974
- Tongue
- English
- Weight
- 318 KB
- Volume
- 251
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/251434a0
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract We investigated the cloning efficiency, DNA repair, and the rate of DNA replication in the skin fibroblasts from patients with Werner's syndrome (WS) of an autosomal recessive premature aging disease. Five WS strains exhibited normal levels of sensitivity toward Xβray and UV killings an
The replication of chromosomal DNA in a series of abnormal human cell cultures has been studied by means of DNA-fiber autoradiography. In lymphocytes with trisomy 21, in fibroblasts of 45,X;47,XXX;49,XXXXY; and 49,XXXXX chromosomal constitution, and in fibroblasts from a patient with xeroderma pigme
Cultures of chick embryo fibroblasts were synchronized using a procedure previously described. The profile of incorporation of tritiated thymidine showed a main peak of nuclear DNA replication followed by a small peak between 18 and 24 hr after induction of the cell division, and representing 10 to