The replication of chromosomal DNA in a series of abnormal human cell cultures has been studied by means of DNA-fiber autoradiography. In lymphocytes with trisomy 21, in fibroblasts of 45,X;47,XXX;49,XXXXY; and 49,XXXXX chromosomal constitution, and in fibroblasts from a patient with xeroderma pigme
โฆ LIBER โฆ
DNA replication in short-time organ cultures of human epidermis
โ Scribed by H. Krokan; G. Volden
- Publisher
- Springer-Verlag
- Year
- 1982
- Tongue
- English
- Weight
- 276 KB
- Volume
- 273
- Category
- Article
- ISSN
- 0340-3696
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Adult and foetal human skin samples maintained in short-term organ culture were treated topically with solutions of coal-tar, creosote or bitumen, then DNA was isolated and analysed by 32P-post-labelling for the presence of aromatic DNA adducts. Autoradiographs of the 32P-labelled adducts resolved o