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Altered plasma membrane ultrastructure in multidrug-resistant cells

โœ Scribed by A.Larry Arsenault; Victor Ling; Norbert Kartner

Book ID
115728463
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
1011 KB
Volume
938
Category
Article
ISSN
0005-2736

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โœ M.Jesรบs Chiquero; Josรฉ M Pรฉrez-Victoria; Francisco Oโ€™Valle; Josรฉ M Gonzรกlez-Ros; ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 444 KB

We selected a Leishmania tropica cell line resistant to daunomycin (DNM) that presents a multidrug-resistant (MDR) phenotype characterized by overexpression of a P-glycoprotein of 150 kDa. The resistant line overexpressed an MDR-like gene, called ltrmdr1, located in an extrachromosomal circular DNA.