We selected a Leishmania tropica cell line resistant to daunomycin (DNM) that presents a multidrug-resistant (MDR) phenotype characterized by overexpression of a P-glycoprotein of 150 kDa. The resistant line overexpressed an MDR-like gene, called ltrmdr1, located in an extrachromosomal circular DNA.
✦ LIBER ✦
Altered Drug Membrane Permeability in a Multidrug-Resistant Leishmania tropica Line
✍ Scribed by M.Jesús Chiquero; José M Pérez-Victoria; Francisco O’Valle; José M González-Ros; Raimundo G del Moral; José A Ferragut; Santiago Castanys; Francisco Gamarro
- Book ID
- 119407421
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 444 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0006-2952
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