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Altered neuregulin 1–erbB4 signaling contributes to NMDA> receptor hypofunction in schizophrenia

✍ Scribed by Hahn, Chang-Gyu; Wang, Hoau-Yan; Cho, Dan-Sung; Talbot, Konrad; Gur, Raquel E; Berrettini, Wade H; Bakshi, Kalindi; Kamins, Joshua; Borgmann-Winter, Karin E; Siegel, Steven J

Book ID
109932863
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
220 KB
Volume
12
Category
Article
ISSN
1078-8956

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Evidence that interaction between neuregulin 1 and its receptor erbB4 increases susceptibility to schizophrenia
✍ Nadine Norton; Valentina Moskvina; Derek W Morris; Nicholas J Bray; Stanley Zamm 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 84 KB

## Abstract There is now strong evidence that Neuregulin 1 (NRG1) is a susceptibility gene for schizophrenia. NRG1 mediates some of its effects through the tyrosine kinase receptor erbB4, and analysis of gene knock‐out animals suggests that the functional interaction of NRG1 and erbB4 mediates beha