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Altered metabolism and decreased efficacy of prednisolone and prednisone in patients with hyperthyroidism

โœ Scribed by Frey, Felix J; Horber, Fritz F; Frey, Brigitte M

Book ID
109844405
Publisher
Nature Publishing Group
Year
1988
Tongue
English
Weight
952 KB
Volume
44
Category
Article
ISSN
0009-9236

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The pharmacokinetics of prednisone and prednisolone was examined in 12 healthy male subjects to assess the bioavailability and the parameters of reversible metabolism between the two steroids. After an oral prednisone dose of 0.8mg kg-' and an intravenous prednisolone dose of 0.66 mg kg-', the bioav