Bioavailability and activity of prednisone and prednisolone in the feline patient
โ Scribed by C. A. Graham-Mize; E. J. Rosser
- Book ID
- 110871297
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 96 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0959-4493
No coin nor oath required. For personal study only.
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The pharmacokinetics of prednisone and prednisolone was examined in 12 healthy male subjects to assess the bioavailability and the parameters of reversible metabolism between the two steroids. After an oral prednisone dose of 0.8mg kg-' and an intravenous prednisolone dose of 0.66 mg kg-', the bioav
The protein binding characteristics of prednisone and prednisolone were determined in human and rabbit plasma and in a 4.7 per cent human serum albumin (HSA) solution. The influence of plednisolone on prednisone binding in human plasma was also examined. Prednisolone exhibited nonlinear binding and