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Altered expression of MRP2, MRP3 and UGT2B1 in the liver affects the disposition of morphine and its glucuronide conjugate in a rat model of cholestasis

✍ Scribed by Yoshitaka Hasegawa; Shuichi Kishimoto; Hirokazu Takahashi; Nobuo Inotsume; Yoshikazu Takeuchi; Shoji Fukushima

Book ID
111770999
Publisher
Pharmaceutical Press
Year
2009
Tongue
English
Weight
329 KB
Volume
61
Category
Article
ISSN
2042-7158

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The hepatobiliary disposition of rhodamine 123 (RH-123) and its glucuronidated (RH-Glu) and deacylated (RH-110) metabolites were studied in an isolated perfused rat liver (IPRL) model in the presence and absence of P-glycoprotein (P-gp) and Mrp2 inhibitors. A single dose (180 mg) of RH-123 was added