Altered dendritic cells with tolerizing phenotype in patients with systemic lupus erythematosus
β Scribed by Yackov Berkun; Inna Verbovetski; Anat Ben-Ami; Daphna Paran; Dan Caspi; Alon Krispin; Uriel Trahtemberg; Oranit Gill; Yaakov Naparstek; Dror Mevorach
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 219 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0014-2980
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## Objective: Systemic lupus erythematosus (sle) is a systemic autoimmune disease characterized by b cell hyperactivity and defective t cell functions, including interleukin-2 production and proliferation. the defects in t cell function may result from underlying defects in antigen-presenting cell
## Abstract We have found subnormal amounts of chemotactic activity in zymosanβtreated sera from 13 of 29 patients with systemic lupus erythematosus (SLE). As an explanation for this abnormality, the presence of a uniquely specific, heatβstable inhibitor of complement (C5)βderived chemotactic activ