๐”– Bobbio Scriptorium
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Altered cellular responsiveness during ageing

โœ Scribed by Suresh I. S. Rattan; Anastassia Derventzi

Book ID
102759712
Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
832 KB
Volume
13
Category
Article
ISSN
0265-9247

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โœฆ Synopsis

Abstract

The capacity of cells and organisms to respond to external stimuli and to maintain stability in order to survive decreases progressively during ageing. The mitogenic and stimulatory effects of growth factors, hormones and other agents are reduced significantly during cellular ageing. The sensitivity of ageing cells to toxic agents including antibiotics, phorbol esters, radiations and heat shock increases. This failure of homeostasis during cellular ageing does not appear to be due to any quantitative and qualitative defects in the receptor systems. Instead, metabolic defects in the pathways of macromolecular synthesis may be the basis of altered cellular responsiveness during ageing.

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