It has recently been suggested that the effects of in utero cocaine exposure may result in subtle deficits related to a challenging environment, including exposure to novelty or stress. This study used a neonatal drug-exposure model to examine the behavioral response to a novel environment in rodent
β¦ LIBER β¦
Altered responsiveness to cocaine in rats exposed to methylphenidate during development
β Scribed by Andersen, Susan L.; Arvanitogiannis, Andreas; Pliakas, Andrea M.; LeBlanc, Celeste; Carlezon, William A.
- Book ID
- 109941179
- Publisher
- Nature Publishing Group
- Year
- 2001
- Tongue
- English
- Weight
- 227 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1097-6256
- DOI
- 10.1038/nn777
No coin nor oath required. For personal study only.
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Cocaine, as does exposure to other physiological stressors, releases brain corticotropin releasing factor (CRF), and this release habituates during the course of repeated cocaine administration in animals. Due to the many signs of anxiety and responses to stress that are produced by cocaine withdraw