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Alterations of the Cell Cycle Regulators Cyclin D1, Cyclin A, p27, p21, p16, and pRb in Apocrine Metaplasia of the Breast

✍ Scribed by Ghada Elayat; Abdel-Ghani A. Selim; Clive A. Wells


Book ID
109079847
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
187 KB
Volume
15
Category
Article
ISSN
1075-122X

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## Abstract Alterations of cell cycle regulatory proteins, especially those that regulate G1 to S transition, have been implicated in the pathogenesis of a wide variety of human tumors. In previous studies we showed that that there is overexpression of cyclin D1 protein predominately in the giant c