Alterations of HLA class I expression in human melanoma xenografts in immunodeficient mice occur frequently and are associated with higher tumorigenicity

Acquisition of tumorigenic potential in

Acquisition of tumorigenic potential in the human myoepithelial HBL100 cell line is associated with decreased expression of HLA class I, class II and integrin β3 and increased expression of c-myc

✍ P. Krief; C. Saint-Ruf; M. Bracke; C. Boucheix; C. Billard; M. Billard; R. Cassi 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 French ⚖ 757 KB

The human breast cell line HBLIOO acquires the capacity to invade normal tissues and to replace them by proliferation in vitro only at high passage levels (HPL). These cells therefore are a useful model for studying tumor progression in vitro. We have analyzed the expression of cell-surface markers