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Alterations of Chk1 and Chk2 expression in colon cancer

✍ Scribed by Magdalena Stawinska; Adam Cygankiewicz; Radzislaw Trzcinski; Michal Mik; Adam Dziki; Wanda M. Krajewska


Book ID
106059612
Publisher
Springer
Year
2008
Tongue
English
Weight
252 KB
Volume
23
Category
Article
ISSN
0179-1958

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The protein encoded by the CHK1 gene plays an important role in the G2 checkpoint in mammalian cells. In its coding region it presents a sequence of nine consecutive adenines that are a potential site of mutations in tumors with microsatellite instability (MSI). We analyzed the presence of frameshif