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Alterations in the suppressor gene PPP2R1B in parathyroid hyperplasias and adenomas

โœ Scribed by Samuli Hemmer; Veli-Matti Wasenius; Caj Haglund; Ying Zhu; Sakari Knuutila; Kaarle Franssila; Heikki Joensuu


Book ID
114135259
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
120 KB
Volume
134
Category
Article
ISSN
0165-4608

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Parathyroid adenomas causing primary hyperparathyroidism (pHPT) frequently exhibit allelic loss of DNA markers on the short arm of chromosome 1, indicating the presence of one or more tumor-suppressor genes on 1p. Since the development of pHPT is enhanced in individuals exposed to ionizing radiation