Alterations in protein synthesis induced by C2 toxin in 3T3 cells
β Scribed by Tatyana Sklyarova; Vladimir Kostyukovski; Vadim Sharov; Victor Prisyazhnoy; Oleg Denisenko
- Book ID
- 115930716
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 743 KB
- Volume
- 363
- Category
- Article
- ISSN
- 0014-5793
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The effects of the anti-cancer anthracyclines doxorubicin and daunorubicin on the activity of protein kinase C (PKC) were examined in intact Swiss 3T3 cells. The 2 drugs stimulated the phosphorylation of an 80K phosphoprotein found to be identical to that generated in response to the PKC activator 1
## Abstract Exogenous ATP has been shown to cause a rapid and reversible increase in permeability in transformed 3T3 cells (3T6 and SV3T3) but not in untransformed 3T3 cells. The cells remain viable, but lose intracellular acidβsoluble pools. Treatment of transformed cells with ATP greatly reduces