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Alterations in contact and density-dependent arrest state in senescent WI-38 cells

โœ Scribed by Robert J. Pignolo; Mitch O. Rotenberg; Vincent J. Cristofalo

Book ID
112801825
Publisher
Society for In Vitro Biology
Year
1994
Tongue
English
Weight
604 KB
Volume
30
Category
Article
ISSN
1475-2689

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When cultures of WI-38 human diploid fibroblasts reach high cell densities, they cease to proliferate and enter a viable state of quiescence. WI-38 cells can remain in this quiescent state for long periods of time; however, the longer the cells remain growth arrested, the more time they require to l