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Alterations in cell death and cell cycle progression in the UV-irradiated epidermis of bcl-2-deficient mice

✍ Scribed by Gillardon, Frank; Moll, Ingrid; Meyer, Michael; Michaelidis, Theologos M


Book ID
110015857
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
326 KB
Volume
6
Category
Article
ISSN
1350-9047

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Previous studies on cell cycle regulation in the ocular lens using transgenic mice have shown that inactivation of the retinoblastoma tumor suppressor protein (pRb) can cause postmitotic lens fiber cells to enter the cell cycle. However, when the p53 gene and protein are intact, inactivation of pRb