Alterations in Cell Cycle Regulation Underlie Cisplatin Induced Apoptosis of Dorsal Root Ganglion Neurons in Vivo
β Scribed by Stephanie J. Fischer; Elizabeth S. McDonald; LouAnn Gross; Anthony J. Windebank
- Book ID
- 115641649
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 481 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0969-9961
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Changes in the number of argyrophilic nucleolar granules (ANGs) caused by cisplatin treatment were studied in sensory neurons isolated from dorsal root ganglia of 12day-old chick embryos. The number of ANGs changed during culture in untreated cultures. The mean number of ANGs per cell was 10.6 f 4.6
## Abstract Neurosteroids are synthesized either by glial cells, by neurons, or within the context of neuronβglia crossβtalk. Various studies suggested neurosteroid involvement in the control of neurodegeneration but there is no evidence showing that the natural protection of nerve cells against ap