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Alteration of DNA and RNA Binding Activity of Human Telomere Binding Proteins Occurs during Cellular Senescence

โœ Scribed by Karen Hubbard; Sridevi N. Dhanaraj; Khalid A. Sethi; Janice Rhodes; Jeffrey Wilusz; Michael B. Small; Harvey L. Ozer


Book ID
115602034
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
561 KB
Volume
218
Category
Article
ISSN
0014-4827

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Cellular senescence is a terminal growth phase characteristic of normal human diploid fibroblasts. Altered gene expression during cellular senescence is numerous compared to that of younger proliferative cells in culture. We have previously reported that the levels and activities of hnRNP A1 and A2