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Synthesis and human telomeric G-quadruplex DNA-binding activity of glucosaminosides of shikonin/alkannin

✍ Scribed by Hao He; Li-Ping Bai; Zhi-Hong Jiang


Book ID
113496575
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
472 KB
Volume
22
Category
Article
ISSN
0960-894X

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## Abstract Human telomeric DNA consists of tandem repeats of the sequence 5′‐d(TTAGGG)‐3β€². Guanine‐rich DNA, such as that seen at telomeres, forms G‐quadruplex secondary structures. Alternative forms of G‐quadruplex structures can have differential effects on activities involved in telomere mainte