𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Alteration of colony-stimulating factor output, endotoxemia, and granulopoiesis in cyclic neutropenia

✍ Scribed by Peter L. Greenberg; Ine Bax; Jack Levin; Tony M. Andrews

Publisher
John Wiley and Sons
Year
1976
Tongue
English
Weight
734 KB
Volume
1
Category
Article
ISSN
0361-8609

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Cellular and humoral factors involved in the regulation of granulopoiesis were evaluated in two patients with cyclic neutropenia by utilizing the agar‐gel marrow culture technique to serially study marrow granulocytic colony‐forming capacity (CFC) and the urinary output of colony‐stimulating factor (CSF). CSF output varied inversely with peripheral neutrophil counts and directly with monocyte counts and evidence for infection (endotoxemia and/or staphylococcal abscesses). Following autologous infusion of one patient's plasma obtained during a period of neutropenia, increased urinary excretion of CSF occurred concomitant with increments in both marrow CFC and the proportion of granulocytic progenitor cells in DNA synthesis. Neutrophil periodicity was not altered by the administration of the neutropenic plasma. These findings are consistent with the hypothesis that cyclic neutropenia is caused by a quantitatively decreased entry of stem cells or granulocytic progenitor cells into granulopoiesis.

📜 SIMILAR VOLUMES

Granulocyte-macrophage-colony stimulatin
Granulocyte-macrophage-colony stimulating factor for prevention of neutropenia and infections in children and adolescents with solid tumors. Results of a prospective randomized study
✍ Stefan E. G. Burdach; Markus Müschenich; Wolfgang Josephs; Jürgen Frisch; Gregor 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 605 KB

Background. Chemotherapy is an essential modality of curative strategies in pediatric oncology. Dose and dose intensity are, above all, restricted by the myelosuppressive effects of cytotoxic drugs. Neutropenia constitutes an important risk of morbidity and mortality. Granulocytemacrophage-colony st

Failure of granulocyte-macrophage colony
Failure of granulocyte-macrophage colony-stimulating factor to reduce febrile neutropenia in children with recurrent solid tumors treated with ifosfamide, carboplatin, and etoposide chemotherapy
✍ Marina, Neyssa M. ;Shema, Sarah J. ;Bowman, Laura C. ;Rodman, John ;Douglass, Ed 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 596 KB

## Abstract Ifosfamide, carboplatin, and etoposide (ICE) chemotherapy has promising activity against various solid tumors but produces significant myelotoxicity that might be ameliorated by hematopoietic growth factors. Twelve patients with relapsed solid tumors were treated with ICE chemotherapy.

Cellular responsiveness to stimulation i
Cellular responsiveness to stimulation in vitro: Increased responsiveness to colony stimulating factor of bone marrow colony-forming cells treated with surface-active agents and cyclic 3′5′ AMP
✍ W. A. Fleming; T. A. McNeill 📂 Article 📅 1976 🏛 John Wiley and Sons 🌐 English ⚖ 484 KB

## Abstract Addition of low concentrations (10 ng/ml) of saponin or Tween 80 to stimulated cultures of normal mouse bone marrow in agar increased the number of granulocyte‐macrophage colonies which developed. Addition of cyclic AMP or dibutyryl cyclic AMP in low concentration (10~−8~ to 10~−10~ M)

Regulation of proliferation in a murine
Regulation of proliferation in a murine colony-stimulating factor-dependent myeloid cell line: Superinduction of C-fos by the growth inhibitor 8-Br-cyclic adenosine 3′:5′ monophosphate
✍ Annick Harel-Bellan; William L. Farrar 📂 Article 📅 1988 🏛 John Wiley and Sons 🌐 English ⚖ 531 KB

We have investigated the effect of 8-Br-cyclic adenosine 3':5' monophosphate (cAMP), a pharmacological activator of cAMP-dependent protein kinase, on the proliferation and the nuclear proto-oncogene induction in a murine granulocyte macrophage colony-stimulating factor (GM-CSF)-dependent myeloid cel