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Alteration of adipokines during peripheral blood stem cell mobilization induced by granulocyte colony-stimulating factor

✍ Scribed by Yoshinori Tanaka; Toshiaki Yujiri; Mayumi Tanaka; Noriyuki Mitani; Atsuko Tanimura; Yukio Tanizawa

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
100 KB
Volume
24
Category
Article
ISSN
0733-2459

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✦ Synopsis

Abstract

Adipokines, soluble mediators produced by adipocytes, have been shown to play a role in various physiological and pathological conditions. We investigated the involvement of adipokines in granulocyte colony‐stimulating factor (G‐CSF)‐induced mobilization of hematopoietic stem cells in 21 healthy donors. We found that serum visfatin and resistin levels, but not leptin and adiponectin levels, were significantly elevated by G‐CSF treatment. G‐CSF treatment activated signaling proteins like extracellular signal‐regulated kinase and stimulated secretion of visfatin from 3T3‐L1 adipocytes. These findings suggest that some adipokines may play a role in G‐CSF‐induced mobilization of stem cells from the bone marrow into systemic circulation. J. Clin. Apheresis 2009. © 2009 Wiley‐Liss, Inc.

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