𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Alpharadiographic and histological observations on the skeletal effects of hypervitaminoses A and D in the rat

✍ Scribed by Bélanger, Leonard F. ;Clark, Irwin

Publisher
John Wiley and Sons
Year
1967
Tongue
English
Weight
803 KB
Volume
158
Category
Article
ISSN
0003-276X

No coin nor oath required. For personal study only.

✦ Synopsis

Male Holtzman rats were fed large doses of vitamin A, D or A and D

for 43 days. Sections of the tibia demineralized in EDTA were submitted to alpharadiography or stained by a variety of procedures, including mucopolysaccharide histochemistry. The results were as follows:

( 1 ) In hypervitaminosis D, slightly increased periosteal apposition of normal bone; greatly increased maturation of osteocytes with lacunar enlargement and confluence, interstitial metachromasia and loss of density (osteocytic osteolysis).

(2) In hypervitaminosis A, large growth of abnormally stained cancellous bone at periosteum and stimulation of osteolysis in new and old bone.

( 3 ) In combined A and D hypervitaminoses, the peripheral apposition rate exceeded that induced by vitamin A or vitamin D alone. The new bone appeared fragile and this combined with increased osteolysis was responsible for a number of spontaneous fractures.

USPHS.

ANAT. REC., 358: 443452.

📜 SIMILAR VOLUMES

The effect of dietary consistency on gro
The effect of dietary consistency on gross and histologic morphology in the craniofacial region of young rats
✍ Bouvier, Marianne ;Hylander, William L. 📂 Article 📅 1984 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 858 KB

Three groups of weanling rats and three groups of juvenile rats were fed diets which differed in physical consistency for periods of 5 and 8 weeks, respectively. In both the weanling and juvenile rats, one group was fed a soft diet, a second group was fed a hard diet, and a third group was initially

The normal level of the various cell typ
The normal level of the various cell types in the anterior pituitaries of mature and immature rats and further observations on cyclic histologic variations
✍ Wolfe, J. M. 📂 Article 📅 1935 🏛 John Wiley and Sons 🌐 English ⚖ 545 KB

We have previously reported (Wolfe and Cleveland, '33) that there are cyclic histologic changes in the anterior hypopliysis of the female rat vhich may be correlated with the various phases of the oestral cycle. I n this study differential cell counts were made on the anterior pituitaries of forty r