To test the hypothesis that the spinal control of micturition involves β£ 1 -adrenoceptors, the urodynamic effects of intrathecal and intraarterial β£ 1 -adrenoceptor blockade on apomorphine-induced bladder activity in rats were studied. Continuous cystometry was performed in conscious female Sprague-
β¦ LIBER β¦
Alpha1-Adrenoceptor Antagonists Improve Bladder Storage Function Through Reduction of Afferent Activity in Rats With Bladder Outlet Obstruction
β Scribed by Junji Yazaki; Ken Aikawa; Keiichi Shishido; Tomohiko Yanagida; Masanori Nomiya; Kei Ishibashi; Nobuhiro Haga; Osamu Yamaguchi
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 274 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0733-2467
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## Abstract ## Aims Ξ±1βblockers improve voiding symptoms through the reduction of prostatic and urethral smooth muscle tone; however, the underlying mechanism of improvement of storage symptoms is not known. Using a rat model of detrusor overactivity caused by cerebral infarction (CI), we undertoo