Effects of spinal α1-adrenoceptor antagonism on bladder activity induced by apomorphine in conscious rats with and without bladder outlet obstruction
✍ Scribed by Osamu Ishizuka; Anders Mattiasson; William D. Steers; Karl-Erik Andersson
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 60 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0733-2467
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✦ Synopsis
To test the hypothesis that the spinal control of micturition involves ␣ 1 -adrenoceptors, the urodynamic effects of intrathecal and intraarterial ␣ 1 -adrenoceptor blockade on apomorphine-induced bladder activity in rats were studied. Continuous cystometry was performed in conscious female Sprague-Dawley rats with and without bladder outflow obstruction.
In normal rats, subcutaneous apomorphine, 30 g/kg, induced bladder activity that was abolished or attenuated by the ␣ 1 -adrenoceptor antagonists indoramin and doxazosin given intrathecally or intra-arterially. In rats with outlet obstruction, apomorphine 30 g/kg caused no change in cystometric parameters. However, at a dose of 100 g/kg the drug induced bladder activity, which was attenuated by intrathecal indoramin or doxazosin.
These results suggest that the bladder activity evoked by apomorphine-stimulation of bulbospinal pathways can be influenced by ␣ 1 -adrenoceptors at the spinal and peripheral levels, both in normal rats and in rats with bladder hypertrophy secondary to outlet obstruction.