## Abstract **Scope:** Naturallyโoccurring chemopreventive agent phenethyl isothiocyanate (PEITC), derived primarily from watercress, has been shown to inhibit cell growth and induce apoptosis in cancer cells. In this study, we examined the potential of PEITC in enhancing cisplatinโinduced apoptosi
Alpha-tocopheryl succinate sensitizes human colon cancer cells to exisulind-induced apoptosis
โ Scribed by Soo-Jeong Lim; Young-Ju Lee; Dae-Hun Park; Eunmyong Lee; Moon-Kyung Choi; Wanseo Park; Kyung-Hee Chun; Han-Gon Choi; Jung Sik Cho
- Publisher
- Springer
- Year
- 2006
- Tongue
- English
- Weight
- 333 KB
- Volume
- 12
- Category
- Article
- ISSN
- 1360-8185
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## Abstract In cervical carcinogenesis, the p53 tumor suppressor pathway is disrupted by HPV (human papilloma virus) E6 oncogene expression. E6 targets p53 for rapid proteasomeโmediated degradation. We therefore investigated whether proteasome inhibition by MG132 could restore wildโtype p53 levels