𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Alpha-synuclein and its role in metal binding: Relevance to Parkinson's disease

✍ Scribed by Josephine A. Wright; David R. Brown

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
153 KB
Volume
86
Category
Article
ISSN
0360-4012

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Parkinson's disease and some other neurodegenerative disorders are associated with a protein that can aggregate and form fibrils called alpha‐synuclein. Like many other proteins associated with neurodegenerative disorders, this protein has no known function, and the mechanism by which it could cause diseases is poorly defined. It was recently suggested that it binds copper. This review assesses what is known about alpha‐synuclein and its interaction with metals. © 2007 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Alpha-synuclein promoter haplotypes and
Alpha-synuclein promoter haplotypes and dementia in Parkinson's Disease
✍ E.V. De Marco; P. Tarantino; F.E. Rocca; G. Provenzano; D. Civitelli; V. De Luca 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 71 KB 👁 3 views

## Abstract Dementia is a common complication of Parkinson's disease (PD). It correlates significantly with the presence of cortical, limbic or nigral Lewy bodies, mainly constituted of alpha‐synuclein. Mutations of the alpha‐synuclein gene (SNCA) have been linked to rare familial forms of PD, whil

Clues to how alpha-synuclein damages neu
Clues to how alpha-synuclein damages neurons in Parkinson's disease
✍ David Sulzer 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 68 KB

## Abstract Alpha‐synuclein (α‐syn) appears to normally regulate neurotransmitter release, possibly via calcium‐dependent binding and dissociation from lipid domains on secretory vesicles. The pathogenic effects of α‐syn leading to Parkinson's disease (PD) appear to result from alternate toxic effe

Alpha-synuclein immunohistochemistry in
Alpha-synuclein immunohistochemistry in two cases of co-occurring idiopathic Parkinson's disease and motor neuron disease
✍ Kevin J. Klos; Keith A. Josephs; Joseph E. Parisi; Dennis W. Dickson 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 288 KB

## Abstract We report on two cases of sporadic idiopathic Parkinson's disease with motor neuron disease co‐occurring in the same individuals. Pathological analysis revealed the presence of Lewy bodies in brainstem nuclei and basal forebrain consistent with Lewy body disease (LBD), as well as motor

Role of amyloid β peptides in the regula
Role of amyloid β peptides in the regulation of central cholinergic function and its relevance to Alzheimer's disease pathology
✍ S. Kar 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 156 KB 👁 1 views

## Abstract The neuropathological features associated with Alzheimer's disease (AD) brain include the presence of extracellular neuritic plaques composed of amyloid β protein (Aβ), intracellular neurofibrillary tangles containing hyperphosphorylated tau protein, and the loss of basal forebrain chol