The presence of a-MSH receptors on human melanoma has so far been suggested in the literature but not proved. We describe a reproducible and specific binding assay of a-MSH on human melanoma cells, using a high-specific-activity 1251labelled hormone (1.5 to 2 mCi/pg) with consistent receptor binding
alpha-Melanocyte-Stimulating Hormone, MSH 11-13 KPV and Adrenocorticotropic Hormone Signalling in Human Keratinocyte Cells
β Scribed by Elliott, Richard J.; Szabo, Marika; Wagner, Mark J.; Kemp, E. Helen; MacNeil, Sheila; Haycock, John W.
- Book ID
- 110733126
- Publisher
- Nature Publishing Group
- Year
- 2004
- Tongue
- English
- Weight
- 622 KB
- Volume
- 122
- Category
- Article
- ISSN
- 0022-202X
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
The common acute lymphoblastic leukemia antigen (CALLA) is identical to human endopeptidase 24.1 I (E-24.1 I) and is expressed on certain human melanoma lines. This work was conducted in order t o investigate whether alphamelanocyte-stimulating hormone (alpha-MSH) could be a substrate for E-24.1 I
D-alpha tocopheryl succinate (vitamin E succinate), which is known to induce differentiation and growth inhibition in murine B-16 melanoma cells, reduced basal and melanocyte-stimulating hormone (MSH)-stimulated adenylate cyclase (AC) activity in vitro. Vitamin E succinate treatment also reduced sod