Alpha tocopheryl succinate inhibits melanocyte-stimulating hormone (MSH)-sensitive adenylate cyclase activity in melanoma cells
✍ Scribed by Satya N. Sahu; Judith Edwards-Prasad; Kedar N. Prasad
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- English
- Weight
- 485 KB
- Volume
- 133
- Category
- Article
- ISSN
- 0021-9541
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✦ Synopsis
D-alpha tocopheryl succinate (vitamin E succinate), which is known to induce differentiation and growth inhibition in murine B-16 melanoma cells, reduced basal and melanocyte-stimulating hormone (MSH)-stimulated adenylate cyclase (AC) activity in vitro. Vitamin E succinate treatment also reduced sodium fluoride-and forskoline-stimulated AC activity of melanoma cells in vitro. Treatment of cells with vitamin E succinate (6 pg/mI)) for a period of 24 hours was sufficient to reduce MSH-stimulated AC activity. Other forms of vitamin E, such as dl-alpha tocopheryl nicotinate, dl-alpha tocopheryl acetate, and dl-alpha tocopherol, which did not affect growth or morphology of melanoma cells, were relatively less effective in altering basal and MSH-stimulated AC activity. Retinoic acid, which inhibited the growth of B-16 melanoma cells, also reduced basal and MSH-, NaF-, and forskolin-stimulated AC activity in