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Allylic protection of thiols and cysteine. III. Use of Fmoc-Cys(Fsam)-OH for solid-phase peptide synthesis

✍ Scribed by Paloma Gomez-Martinez; François Guibé; Fernando Albericio

Book ID
105578741
Publisher
Springer Netherlands
Year
2000
Tongue
English
Weight
544 KB
Volume
7
Category
Article
ISSN
1573-3149

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Solid-phase synthesis of peptides using
Solid-phase synthesis of peptides using allylic anchoring groups 2. Palladium-catalysed cleavage of Fmoc-protected peptides
✍ Paul Lloyd-Williams; Ahmed Merzouk; François Guibé; Fernando Albericio; Ernest G 📂 Article 📅 1994 🏛 Elsevier Science 🌐 French ⚖ 384 KB

High yklds for the cleavage reaction of Fmoc-protected peptide segments fmn an allylic handle may be obtained using tributyltin hydride in the jmsence of (ph3P)PdQ in a 1:l mixture of DMF/DCM. Altematively tbe cleavage reacdon may be carried out using NMA as nuclecpbile in a 2:2:1 mixture of DMSOfl'