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Allosteric modulation of peripheral sigma binding sites by a new selective ligand: SR 31747

✍ Scribed by Raymond Paul; Serge Lavastre; Daniel Floutard; Régine Floutard; Xavier Canat; Pierre Casellas; Gérard Le Fur; Jean-Claude Brelière


Book ID
119108775
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
917 KB
Volume
52
Category
Article
ISSN
0165-5728

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Trishomocubanes, a new class of selectiv
✍ Michael Kassiou; Vu H. Nguyen; Robert Knott; MacDonald J. Christie; Trevor W. Ha 📂 Article 📅 1996 🏛 Elsevier Science 🌐 English ⚖ 279 KB

The synthesis, receptor binding, and preliminary structural characterisation of trishomocubanes of types pentacyclo [5.4.0.02'6.03'l°.05'9]undecylamines and 4-azahexacyclo[5.4.1.0E'6.03'l°.05'9.08'll]dodecanes are described. These ligands demonstrated high selectivity and affinity for the sigma bind