Allopurinol-induced pure red cell aplasia
β Scribed by Prashant Shankar; Leo Aish; Hani Hassoun
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 40 KB
- Volume
- 73
- Category
- Article
- ISSN
- 0361-8609
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Several investigators have reported patients with acute pure red cell aplasia (PRCA) caused by anticonvulsants, antibiotics, or antithyroid agents. Allopurinol is known to be a causative agent of aplastic anemia, but there have been few reports of acute PRCA induced by allopurinol. We describe here
logic diagnoses of these patients were confirmed by a positive Ham's test and flow cytometric demonstration of deficiency of GPI-linked proteins. There were 6 men and 3 women. The median age at diagnosis was 32 (range, 20-44) years. One patient died 5 years after diagnosis, while another defaulted a