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Allometric relationships between the pharmacokinetics of propofol in rats, children and adults

✍ Scribed by Catherijne A. J. Knibbe; Klaas P. Zuideveld; Leon P. H. J. Aarts; Paul F. M. Kuks; Meindert Danhof

Book ID
108640311
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
133 KB
Volume
59
Category
Article
ISSN
0306-5251

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Endotoxemia decreases the dose requirement for anesthetics but no data are available for propofol. A rat model was used in which the influence of endotoxin administration on the pharmacokinetics and pharmacodynamics of propofol was investigated. Chronically instrumented rats were randomly allocated