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Allograft incorporation: A biomechanical evaluation in a rat model

✍ Scribed by Dr. Richard R. Pelker; James McKay Jr.; Nancy Troiano; Manohar M. Panjabi; Gary E. Friedlaender

Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
405 KB
Volume
7
Category
Article
ISSN
0736-0266

No coin nor oath required. For personal study only.

✦ Synopsis

Allogeneic bone from Sprague-Dawley rat femurs was subjected to levels of freezing and/or irradiation that are known to have produced changes in the associated immune responses to these grafts. This bone was transplanted into an experimentally created gap in the femur of Lewis rats. The subsequent healing of the transplants in the Lewis rats was studied at 2, 4, 8, and 16 weeks after transplantation using torsion testing to failure. There was no clear advantageous biologic response in the union of the grafted material accompanying the alterations in immunologic response as measured by biomechanical testing of the proximal osteosynthesis site in torsion. The torsional strength of all of these groups remained lower than that of intact bone. Furthermore, none of the frozen and/or irradiated allografts exceeded the strength of the fresh allograft at a statistically significant level.

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