Allogeneic marrow transplantation for chronic granulocytic leukemia

✍ Scribed by Speck, B. ;Gratwohl, A. ;Nissen, C. ;Osterwalder, B. ;M�ller, M. ;Bannert, P. ;M�ller, Hj. ;Jeannet, M.

• Publisher: Springer-Verlag
• Year: 1982
• Weight: 314 KB
• Volume: 45
• Category: Article
• ISSN: 1432-0584
• DOI: 10.1007/bf00320190

✦ Synopsis

Six patients with Philadelphia-chromosome (Ph' +)-positive chronic granulocytic leukemia were transplanted from their HLA-identical siblings after conditioning with cyclophosphamide and 1'000 rad total body irradiation. All received cyclosporin-A for prophylaxis of Graft-versus-Host disease. All patients showed prompt engraftment and all are cytogenetically and clinically in complete remission. Two patients had transient mild signs of Graft-versus-Host-disease and one patient had unilateral facial nerve paresis of unknown origin. All are ambulatory and well 6-18 months (median 10 months) after transplantation.