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Allergy and glioma risk: Test of association by genotype

✍ Scribed by Sara E. Dobbins; Fay J. Hosking; Sanjay Shete; Georgina Armstrong; Anthony Swerdlow; Yanhong Liu; Robert Yu; Ching Lau; Minouk J. Schoemaker; Sarah J. Hepworth; Kenneth Muir; Melissa Bondy; Richard S. Houlston

Publisher
John Wiley and Sons
Year
2010
Tongue
French
Weight
176 KB
Volume
128
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

Although epidemiological studies have suggested an association between atopy and glioma risk, these observations have been based on self‐reporting of allergic conditions raising the possibility that associations may be noncausal and arise as a consequence of bias, reverse causation or other artifacts. Genetic information provides an alternative approach to investigate the relationship avoiding such biases. We analyzed 1,878 glioma cases and 3,670 controls for variants at 2q12, 5q12.1, 11q13 and 17q21 that are associated with asthma or eczema risk at p < 5.0 Γ— 10^βˆ’7^. The SNP rs7216389, which tags the 3β€² flanking region of ORMDL3 at 17q21 and has been associated with childhood asthma, was correlated with increased glioma risk (OR = 1.10; 95% CI: 1.01–1.19). These data provide evidence for a correlation between asthma susceptibility and glioma risk and illustrate the value of using genetics as an investigative tool for developing etiological hypotheses.

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