𝔖 Bobbio Scriptorium
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Allergic contact dermatitis to various salols (phenyl salicylates)

✍ Scribed by Bernard Marchand; Pierre Barbier; Georges Ducombs; Jean Foussereau; Pierre Martin; Claude Benezra


Publisher
Springer-Verlag
Year
1981
Tongue
English
Weight
326 KB
Volume
272
Category
Article
ISSN
0340-3696

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✦ Synopsis


Patients sensitive to phenyl salicylate (salol) were patch-tested to several aryl salicylates. The most powerful derivative was p-nitrophenyl salicylate (compound 5). This can be explained by an unusually good interaction with protein (nucleophilic substitution on the carboxyl carbon). All these results were confirmed by experimental sensitization of guinea pigs to salol and crossreaction to substituted salols. The results are in line with current theory of allergic contact dermatitis, i.e., an in vivo formation of a hapten-protein conjugate.


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