Allergen gene transfer

✍ Scribed by Shau-Ku Huang; Kaw-Yan Chua; Kue-Hsiung Hsieh

• Book ID: 104358794
• Publisher: Elsevier Science
• Year: 1997
• Tongue: English
• Weight: 512 KB
• Volume: 9
• Category: Article
• ISSN: 0952-7915
• DOI: 10.1016/s0952-7915(97)80181-1

✦ Synopsis

DNA-based immunization induces a biased Th1 immune response, and offers a novel strategy for modulation of the Th2-associated response. Recent studies have provided evidence that antigen-induced allergic responses can be modulated in rodents immunized with plasmid DNAs encoding the sensitizing antigens. Further understanding of the regulatory mechanism involved and optimization of gene transfer/expression systems will assist greatly in proving the clinical utility of this process.