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Allenic cholesteryl derivatives as inhibitors of ecdysone biosynthesis

✍ Scribed by Alain Burger; Jean-Pierre Roussel; Charles Hetru; Jules A. Hoffmann; Bang Luu

Book ID
107857377
Publisher
Elsevier Science
Year
1989
Tongue
French
Weight
712 KB
Volume
45
Category
Article
ISSN
0040-4020

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πŸ“œ SIMILAR VOLUMES

Synthesis of an ecdysteroid inhibitor of
Synthesis of an ecdysteroid inhibitor of ecdysone biosynthesis
✍ Antony Mauvais; Charles Hetru; Bang Luu πŸ“‚ Article πŸ“… 1991 πŸ› Elsevier Science 🌐 French βš– 178 KB

The hydroboration-oxidation of a A5.7 pregnadiene leads to a A7 6a-hydroxyderivative. This is converted to an acetylenic analogue of ecdysteroids, which is an inhibitor of their biosynthesis in vitro. Several acetylenic cholesteryl derivatives have been reported by our group to irreversibly inhibit