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Acetylenic Inhibitors of C-22 Hydroxylase of Ecdysone Biosynthesis

✍ Scribed by A. Mauvais; A. Burger; J.P. Roussel; C. Hetru; B. Luu

Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
725 KB
Volume
22
Category
Article
ISSN
0045-2068

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πŸ“œ SIMILAR VOLUMES

Synthesis of an ecdysteroid inhibitor of
Synthesis of an ecdysteroid inhibitor of ecdysone biosynthesis
✍ Antony Mauvais; Charles Hetru; Bang Luu πŸ“‚ Article πŸ“… 1991 πŸ› Elsevier Science 🌐 French βš– 178 KB

The hydroboration-oxidation of a A5.7 pregnadiene leads to a A7 6a-hydroxyderivative. This is converted to an acetylenic analogue of ecdysteroids, which is an inhibitor of their biosynthesis in vitro. Several acetylenic cholesteryl derivatives have been reported by our group to irreversibly inhibit