Allelotype profiles of local recurrences and distant metastases from colorectal-cancer patients

✍ Scribed by Lin Thorstensen; Hanno Qvist; Jahn M. Nesland; Karl-Erik Giercksky; Ragnhild A. Lothe

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: French
• Weight: 543 KB
• Volume: 69
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/(sici)1097-0215(19961220)69:6<452::aid-ijc6>3.0.co;2-3

✦ Synopsis

Several genetic alterations have been described in benign and malignant primary tumors of the colorectum, but few such associations have been made with the progression of these tumors. This study compares genetic changes found in distant metastases (n = 22) with local recurrences (n = IS) as well as with primary carcinomas (n = 12). Complete allelotypes of the tumors were obtained by analyzing 43 microsatellite loci, representing all non-acrocentric chromosome arms and mapping to the mid-portion of the arms. Allelic imbalances in the tumor DNA were evaluated by comparison with the patient's constitutional pattern in blood DNA. The allelotype profile of the distant metastases was different from those found in the local recurrences and in the primary carcinomas. More than