Cancer of the low and middle rectum: Local and distant recurrences, and survival in 350 radically resected patients

✍ Scribed by Bozzetti, Federico; Mariani, Luigi; Miceli, Rosalba; Doci, Roberto; Montalto, Fabrizio; Andreola, Salvatore; Gennari, Leandro

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 562 KB
• Volume: 62
• Category: Article
• ISSN: 0022-4790
• DOI: 10.1002/(sici)1096-9098(199607)62:3<207::aid-jso11>3.0.co;2-3

✦ Synopsis

The purpose of this study was to compare local recurrence, distant metastases, and survival rate in 350 patients with cancer of the middle and low rectum who underwent a radical abdominoperineal resection (APER) or a sphincter-saving resection (SSR) in our Institute.

There were 257 APER patients and 93 SSR patients, with a median follow-up of 77 months. At 5 years, the estimates in APER and SSR patients were respectively 1 1 % and 30% for the incidence of pelvic recurrence, 18% and 8% for the incidence of distant metastases, and 64% and 73% for overall survival.

In the multivariate analysis it was found that Dukes' stage significantly affected pelvic recurrences, distant metastases rate and overall survival; histologic type affected only the pelvic recurrence rate. However, the final outcome of patients following APER or SSR was similar, suggesting that local failure per se does not affect long-term survival.