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Allelic Variation in Gene Expression Is Common in the Human Genome

โœ Scribed by Lo, H. Shuen (author);Wang, Zhining (author);Hu, Ying (author);Yang, Howard H. (author);Gere, Sheryl (author);Buetow, Kenneth H. (author);Lee, Maxwell P. (author)

Book ID
124084441
Publisher
Cold Spring Harbor Laboratory
Year
2003
Tongue
English
Weight
777 KB
Volume
13
Category
Article
ISSN
1088-9051

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Background and Procedure. The p53 gene homologue, p73, is located on the 1p36-3 locus, which is frequently deleted in human neuroblastoma (NB). A survey of 61 NB showed that among 33% of informative cases, p73 loss of heterozygosity (LOH) occurred in 7 of 20 (35%). Results. LOH pattern of vicinal ma